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cells invivogen thpd nfis hs27 atcc crl 1634 thp1 dual ko sting cells invivogen thpd kostg experimental models
Cells Invivogen Thpd Nfis Hs27 Atcc Crl 1634 Thp1 Dual Ko Sting Cells Invivogen Thpd Kostg Experimental Models, supplied by InvivoGen, used in various techniques. Bioz Stars score: 98/100, based on 373 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/thp1+dual+ko+sting/THP1-Dual+Cells/pm42030932-531-5-6
Average 98 stars, based on 373 article reviews
Cells Invivogen Thpd Nfis Hs27 Atcc Crl 1634 Thp1 Dual Ko Sting Cells Invivogen Thpd Kostg Experimental Models, supplied by InvivoGen, used in various techniques. Bioz Stars score: 98/100, based on 373 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/thp1+dual+ko+sting/THP1-Dual+Cells/pm42030932-531-5-6
Average 98 stars, based on 373 article reviews
cells invivogen thpd nfis hs27 atcc crl 1634 thp1 dual ko sting cells invivogen thpd kostg experimental models - by Bioz Stars,
2026-10
98/100 stars
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other:Article Title: Investigation of the enhanced antitumour potency of STING agonist after conjugation to polymer nanoparticles. Article Snippet: Intravenously administered cyclic dinucleotides and other STING agonists are hampered by low cellular uptake and poor circulatory half-life.. Here we report the covalent conjugation of cyclic dinucleotides to poly(β-amino ester) nanoparticles through a cathepsin-sensitive linker.. This is shown to increase stability and loading, thereby expanding the therapeutic window in multiple syngeneic tumour models, enabling the study of how the long-term fate of the nanoparticles affects the immune response. Article Title: Cellular RNA and DNA sensing pathways are essential for the dose-dependent response of human monocytes to ionizing radiation Article Snippet: The acute monocytic leukemia cell line THP1 (ATCC) was maintained at 37°C and 5% CO 2 in RPMI-1640 media supplemented with 10% FBS, penicillin/streptomycin, and L-Glutamine. Cell Culture:Article Title: Tumor cell-directed STING agonist antibody-drug conjugates induce type III interferons and anti-tumor innate immune responses. Article Snippet: OVCAR3 (ATCC;HTB-161) cells were cultured inRPMI 1640with 20% FBS, 1% Penicillin/Streptomycin. .. THP1-Dual (Cat# thpd-nfis) and Gene Knockout:Article Title: XMT-2056, a HER2-Directed STING Agonist Antibody–Drug Conjugate, Induces Innate Antitumor Immune Responses by Acting on Cancer Cells and Tumor-Resident Immune Cells Article Snippet: .. Cell suspensions of THP1 reporter cell lines (THP1-Dual (thpd-nfis), THP1-Dual KI-hSTING-H232 (thpd-h232), THP1-Dual KI-hSTING-R232 (thpd-r232), and Incubation:Article Title: XMT-2056, a HER2-Directed STING Agonist Antibody–Drug Conjugate, Induces Innate Antitumor Immune Responses by Acting on Cancer Cells and Tumor-Resident Immune Cells Article Snippet: .. Cell suspensions of THP1 reporter cell lines (THP1-Dual (thpd-nfis), THP1-Dual KI-hSTING-H232 (thpd-h232), THP1-Dual KI-hSTING-R232 (thpd-r232), and Multiple Displacement Amplification:Article Title: Article Snippet: Validation of the Biolegend antibodies are shown on the corresponding product pages on the BioLegend website (traceable from catalog numbers). .. Cell Lines Used: HCC1954 (ATCC; CRL-2338), MDA-MB-175-VII (ATCC; HTB-25), Kuramochi (JCRB; #JCRB0098), Calu-3 (ATCC; HTB-55), OVCAR3 (ATCC; HTB-161), THP1-Dual (Invivogen, Cat# thpd-nfis), |
![XMT-2056 elicits potent antigen-dependent and Fc-R–mediated activation of monocytes in cocultures. A, Schematic of the XMT-2056 mechanism, which includes HER2-dependent ADC uptake into tumor cells and Fcγ-R–expressing myeloid cells. B, Chemical structure of XMT-2056. C, Cytokine induction as measured by a multiplex Luminex assay from supernatants of fresh human WBCs treated for 6 (IFN-β) or 24 (CXCL10, IL-6, and TNF-a) hours. Bars represent mean value of n = 2 data points shown as symbols. D, Competition with trastuzumab by biolayer interferometry (Octet): trastuzumab was loaded onto the sensor chip, and HER2 ECD or HT19 antibody associations are indicated by blue arrows. Additional binding by HT19 indicates noncompetitive binding. E, Competition with trastuzumab by cell-based flow cytometry. HT19 hIgG1 or mIgG2a formats detected with either Alexa Fluor anti-hIgG1 (h647) or Alexa Fluor anti-mIgG2a (m647) secondary antibodies in the presence or absence of trastuzumab–mIgG2a. Each point represents the mean and SD ( n = 3). F, Binding of XMT-2056 or HT19 antibody to HCC1954 cells showing fluorescence intensities measured by flow cytometry. Each point represents the mean and SD ( n = 2). G, CXCL10 cytokine induction in HCC1954 monocultures treated for 24 hours with XMT-2056, nonbinding control ADC, HT19, or the free payload. Each point represents the mean and SD ( n = 2). H, Binding of XMT-2056 or Fc-mutant XMT-2056, HT19, and nonbinding control ADC to SKOV3 cells showing fluorescence intensities measured by flow cytometry. Each point represents the mean and SD ( n = 3). I and J, IRF3 reporter activity of <t>THP1</t> cells in coculture with SKOV3 cells ( I ) or cultured on recombinant HER2 antigen-coated plates ( J ) treated for 24 hours with XMT-2056 or Fc-mutant XMT-2056, nonbinding control ADC, or STING agonist payload. Each point represents the mean and SD ( n = 3). When noted, EC 50 and B max values represent mean of two independent experiments. gMFI, geometric mean fluorescence intensity; RLU, relative light units. ( A, Created in BioRender. Cetinbas, N. [2025], https://BioRender.com/s16c825 ; G, Created in BioRender. Cetinbas, N. [2025], https://BioRender.com/s16c825 ; I and J, Created in BioRender. Cetinbas, N. [2025], https://BioRender.com/s16c825 .)](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_0966/pmc12010966/pmc12010966__ccr-24-2449_f1.jpg)